1. Sohara, E. et al. Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation. Proc Natl Acad Sci U S A 103, 14217-14222, doi:10.1073/pnas.0602331103 (2006).

2. Yang, H. Y. et al. Transgenic overexpression of the secreted, extracellular EGF-CUB domain-containing protein SCUBE3 induces cardiac hypertrophy in mice. Cardiovasc Res 75, 139-147, doi:10.1016/j.cardiores.2007.03.014 (2007).

3. Chang, N. S., Hsu, L. J., Lin, Y. S., Lai, F. J. & Sheu, H. M. WW domain-containing oxidoreductase: a candidate tumor suppressor. Trends Mol Med 13, 12-22, doi:10.1016/j.molmed.2006.11.006 (2007).

4. Su KY, Chien WL, Fu WM, Yu IS, Huang HP, Huang PH, Lin SR, Shih JY, Lin YL, Hsueh YP, Yang PC, Lin SW. Mice deficient in collapsin response mediator protein-1 exhibit impaired long-term potentiation and impaired spatial learning and memory. J Neurosci. 2007 Mar 7;27(10):2513-24.

5. Liu CL, Yu IS, Pan HW, Lin SW, Hsu HC. L2dtl is essential for cell survival and nuclear division in early mouse embryonic development. J Biol Chem. 2007 Jan 12;282(2):1109-18. Epub 2006 Nov 15.

6. Lin H, Cheng CF, Hou HH, Lian WS, Chao YC, Ciou YY, Djoko B, Tsai MT, Cheng CJ, Yang RB. Disruption of guanylyl cyclase-G protects against acute renal injury. J Am Soc Nephrol. 2008 Feb;19(2):339-48. Epub 2008 Jan 16.

7. Tu CF, Yan YT, Wu SY, Djoko B, Tsai MT, Cheng CJ, Yang RB. Domain and functional analysis of a novel platelet-endothelial cell surface protein, SCUBE1. J Biol Chem. 2008 May 2;283(18):12478-88. Epub 2008 Feb 26.

8. Lin YH, Lin YM, Wang YY, Yu IS, Lin YW, Wang YH, Wu CM, Pan HA, Chao SC, Yen PH, Lin SW, Kuo PL. The expression level of septin12 is critical for spermiogenesis. Am J Pathol. 2009 May;174(5):1857-68. Epub 2009 Apr 9.

9. Wu YM, Kao CY, Huang YJ, Yu IS, Lee HS, Lai HS, Lee PH, Lin CN, Lin SW. Genetic modification of donor hepatocytes improves therapeutic efficacy for hemophilia B in mice. Cell Transplant. 2010;19(9):1169-80. Epub 2010 Apr 21.

10. Lin CN, Kao CY, Miao CH, Hamaguchi N, Wu HL, Shi GY, Liu YL, High KA, Lin SW. Generation of a novel factor IX with augmented clotting activities in vitro and in vivo. J Thromb Haemost. 2010 Aug;8(8):1773-83. doi: 10.1111/j.1538-7836.2010.03913.x. Epub 2010 May 21.

11. Yang SS, Lo YF, Yu IS, Lin SW, Chang TH, Hsu YJ, Chao TK, Sytwu HK, Uchida S, Sasaki S, Lin SH. Generation and analysis of the thiazide-sensitive Na+ -Cl- cotransporter (Ncc/Slc12a3) Ser707X knockin mouse as a model of Gitelman syndrome. Hum Mutat. 2010 Dec;31(12):1304-15. doi: 10.1002/humu.21364. Epub 2010 Oct 14.

12. Yang SS, Lo YF, Wu CC, Lin SW, Yeh CJ, Chu P, Sytwu HK, Uchida S, Sasaki S, Lin SH. SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction. J Am Soc Nephrol. 2010 Nov;21(11):1868-77. Epub 2010 Sep 2.

13. Kao CY, Lin CN, Yu IS, Tao MH, Wu HL, Shi GY, Yang YL, Kao JT, Lin SW. FIX-Triple, a gain-of-function factor IX variant, improves haemostasis in mouse models without increased risk of thrombosis. Thromb Haemost. 2010 Aug;104(2):355-65. Epub 2010 Jun 10.

14. Lo YF, Yang SS, Seki G, Yamada H, Horita S, Yamazaki O, Fujita T, Usui T, Tsai JD, Yu IS, Lin SW, Lin SH. Severe metabolic acidosis causes early lethality in NBC1 W516X knock-in mice as a model of human isolated proximal renal tubular acidosis. Kidney Int. 2011 Apr;79(7):730-41. Epub 2011 Jan 12.

15. Lin YH, Chou CK, Hung YC, Yu IS, Pan HA, Lin SW, Kuo PL. SEPT12 deficiency causes sperm nucleus damage and developmental arrest of preimplantation embryos. Fertil Steril. 2011 Jan;95(1):363-5.

16. Huang HP, Hong CL, Kao CY, Lin SW, Lin SR, Wu HL, Shi GY, You LR, Wu CL, Yu IS. Gene targeting and expression analysis of mouse Tem1/endosialin using a lacZ reporter. Gene Expr Patterns. 2011 Jun-Jul;11(5-6):316-26. Epub 2011 Mar 22.

17. Lu YC, Wu CC, Shen WS, Yang TH, Yeh TH, Chen PJ, Yu IS, Lin SW, Wong JM, Chang Q, Lin X, Hsu CJ. Establishment of a knock-in mouse model with the SLC26A4 c.919-2A>G mutation and characterization of its pathology. PLoS One. 2011;6(7):e22150. Epub 2011 Jul 21.

18. Hsu YH, Chen WY, Chan CH, Wu CH, Sun ZJ, Chang MS. Anti-IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss. J Exp Med. 2011 Aug 29;208(9):1849-61. Epub 2011 Aug 15.

19. Chuang HC, Lan JL, Chen DY, Yang CY, Chen YM, Li JP, Huang CY, Liu PE, Wang X, Tan TH. The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells. Nat Immunol. 2011 Oct 9;12(11):1113-8. doi: 10.1038/ni.2121.

20. Lin SH, Yu IS, Jiang ST, Lin SW, Chu P, Chen A, Sytwu HK, Sohara E, Uchida S, Sasaki S, Yang SS. Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17538-43. Epub 2011 Oct 4.

21. Huang CY, Lin YC, Hsiao WY, Liao FH, Huang PY, Tan TH. DUSP4 deficiency enhances CD25 expression and CD4+ T-cell proliferation without impeding T-cell development. Eur J Immunol. 2012 Feb;42(2):476-88. doi: 10.1002/eji.201041295. Epub 2011 Dec 27.

22. Kao CY, Lin CN, Yang YL, Hamaguchi N, Yang SJ, Shen MC, Kao JT, Lin SW. Characterisation of factor IX with a glycine-to-valine missense mutation at residue 190 in a patient with severe haemophilia B. Thromb Haemost. 2011 Apr;105(4):616-26. Epub 2011 Feb 8.

23. Hsu YC, Huang HP, Yu IS, Su KY, Lin SR, Lin WC, Wu HL, Shi GY, Tao MH, Kao CH, Wu YM, Martin PE, Lin SY, Yang PC, Lin SW. Serine protease hepsin regulates hepatocyte size and hemodynamic retention of tumor cells via hepatocyte growth factor signaling. Hepatology. 2012 Apr 13. doi: 10.1002/hep.25773. [Epub ahead of print]

24. Chen CH, Chu PC, Lee L, Lien HW, Lin TL, Fan CC, Chi P, Huang CJ, Chang MS. Disruption of Murine mp29/Syf2/Ntc31 Gene Results in Embryonic Lethality with Aberrant Checkpoint Response. PLoS One. 2012;7(3):e33538. Epub 2012 Mar 20.

25. Hee SW, Tsai SH, Chang YC, Chang CJ, Yu IS, Lee PC, Lee WJ, Yun-Chia Chang E, Chuang LM. The Role of Nocturnin in Early Adipogenesis and Modulation of Systemic Insulin Resistance in Human. Obesity (Silver Spring). 2012 Feb 14. doi: 10.1038/oby.2012.37. [Epub ahead of print]

26. Ma CY, Shi GY, Shi CS, Kao YC, Lin SW, Wu HL. Monocytic Thrombomodulin Triggers LPS- and Gram-Negative Bacteria-Induced Inflammatory Response. J Immunol. 2012 Jun 15;188(12):6328-37. Epub 2012 May 9.

27. Hsu YH, Chen WY, Chan CH, Wu CH, Sun ZJ, Chang MS. Anti-IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss. J Exp Med. 2011 Aug 29;208(9):1849-61. Epub 2011 Aug 15.

28. Chuang HC, Lan JL, Chen DY, Yang CY, Chen YM, Li JP, Huang CY, Liu PE, Wang X, Tan TH. The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells. Nat Immunol. 2011 Oct 9;12(11):1113-8. doi: 10.1038/ni.2121.

29. Lin SH, Yu IS, Jiang ST, Lin SW, Chu P, Chen A, Sytwu HK, Sohara E, Uchida S, Sasaki S, Yang SS. Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17538-43. Epub 2011 Oct 4.

30. Hsu YC, Huang HP, Yu IS, Su KY, Lin SR, Lin WC, Wu HL, Shi GY, Tao MH, Kao CH, Wu YM, Martin PE, Lin SY, Yang PC, Lin SW. Serine protease hepsin regulates hepatocyte size and hemodynamic retention of tumor cells via hepatocyte growth factor signaling. Hepatology. 2012 Apr 13. doi: 10.1002/hep.25773. [Epub ahead of print]

31. Tsai WC, Hsu SD, Hsu CS, Lai TC, Chen SJ, Shen R, Huang Y, Chen HC, Lee CH, Tsai TF, Hsu MT, Wu JC, Huang HD, Shiao MS, Hsiao M, Tsou AP. MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis. J Clin Invest. 2012 Aug 1;122(8):2884-97. doi: 10.1172/JCI63455. Epub 2012 Jul 23.

32. Chen CY, Tsai MS, Lin CY, Yu IS, Chen YT, Lin SR, Juan LW, Chen YT, Hsu HM, Lee LJ, Lin SW. Rescue of the genetically engineered Cul4b mutant mouse as a potential model for human X-linked mental retardation. Hum Mol Genet. 2012 Oct 1;21(19):4270-85. doi: 10.1093/hmg/dds261. Epub 2012 Jul 3.

33. Chen KR, Chang CH, Huang CY, Lin CY, Lin WY, Lo YC, Yang CY, Hsing EW, Chen LF, Shih SR, Shiau AL, Lei HY, Tan TH, Ling P. TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity. J Biol Chem. 2012 Sep 14;287(38):32216-21. doi: 10.1074/jbc.C112.394346. Epub 2012 Jul 25.

34. Chen YT, Tsai MS, Yang TL, Ku AT, Huang KH, Huang CY, Chou FJ, Fan HH, Hong JB, Yen ST, Wang WL, Lin CC, Hsu YC, Su KY, Su IC, Jang CW, Behringer RR, Favaro R, Nicolis SK, Chien CL, Lin SW, Yu IS.R26R-GR: a Cre-activable dual fluorescent protein reporter mouse. PLoS One. 2012;7(9):e46171. doi: 10.1371/journal.pone.0046171. Epub 2012 Sep 25.

35. Chou SH, Ko BS, Chiou JS, Hsu YC, Tsai MH, Chiu YC, Yu IS, Lin SW, Hou HA, Kuo YY, Lin HM, Wu MF, Chou WC, Tien HF. A knock-in Npm1 mutation in mice results in myeloproliferation and implies a perturbation in hematopoietic microenvironment. PLoS One. 2012;7(11):e49769. doi: 10.1371/journal.pone.0049769. Epub 2012 Nov 30.

42. Lu YC, Wu CC, Yang TH, Lin YH, Yu IS, Lin SW, Chang Q, Lin X, Wong JM, Hsu CJ. Differences in the pathogenicity of the p.H723R mutation of the common deafness-associated SLC26A4 gene in humans and mice. PLoS One. 2013 Jun 3;8(6):e64906. doi: 10.1371/journal.pone.0064906. Print 2013.

43. Kao CY, Yang SJ, Tao MH, Jeng YM, Yu IS, Lin SW. Incorporation of the factor IX Padua mutation into FIX-Triple improves clotting activity in vitro and in vivo. Thromb Haemost. 2013 Aug;110(2):244-56. doi: 10.1160/TH13-02-0154. Epub 2013 May 16.

44. Chu PY, Cheng CJ, Wu YC, Fang YW, Chau T, Uchida S, Sasaki S, Yang SS, Lin SH. SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation. PLoS One. 2013 Sep 11;8(9):e72969. doi: 10.1371/journal.pone.0072969. eCollection 2013.

45. Tseng LT, Lin CL, Tzen KY, Chang SC, Chang MF. LMBD1 protein serves as a specific adaptor for insulin receptor internalization. J Biol Chem. 2013 Nov 8;288(45):32424-32. doi: 10.1074/jbc.M113.479527. Epub 2013 Sep 27.

46. Yang SS, Fang YW, Tseng MH, Chu PY, Yu IS, Wu HC, Lin SW, Chau T, Uchida S, Sasaki S, Lin YF, Sytwu HK, Lin SH. Phosphorylation regulates NCC stability and transporter activity in vivo. J Am Soc Nephrol. 2013 Oct;24(10):1587-97. doi: 10.1681/ASN.2012070742. Epub 2013 Jul 5.

47. Kuo PL, Chiang HS, Wang YY, Kuo YC, Chen MF, Yu IS, Teng YN, Lin SW, Lin YH. SEPT12-microtubule complexes are required for sperm head and tail formation. Int J Mol Sci. 2013 Nov 7;14(11):22102-16. doi: 10.3390/ijms141122102.

48. Lee NC, Shieh YD, Chien YH, Tzen KY, Yu IS, Chen PW, Hu MH, Hu MK, Muramatsu S, Ichinose H, Hwu WL. Regulation of the dopaminergic system in a murine model of aromatic L-amino acid decarboxylase deficiency. Neurobiol Dis. 2013 Apr;52:177-90. doi: 10.1016/j.nbd.2012.12.005. Epub 2012 Dec 26

49. Ho BC, Yu IS, Lu LF, Rudensky A, Chen HY, Tsai CW, Chang YL, Wu CT, Chang LY, Shih SR, Lin SW, Lee CN, Yang PC, Yu SL. Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon. Nat Commun. 2014;5:3344. doi: 10.1038/ncomms4344.

50. Liu KM, Wu JY, Chen YT. Mouse model of glycogen storage disease type III. Mol Genet Metab. 2014 Apr;111(4):467-76. doi: 10.1016/j.ymgme.2014.02.005. Epub 2014 Feb 18.

51. Yang CY, Li JP, Chiu LL, Lan JL, Chen DY, Chuang HC, Huang CY, Tan TH. Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation. J Immunol. 2014 Feb 15;192(4):1547-57. doi: 10.4049/jimmunol.1300989. Epub 2014 Jan 8.

52. Lee NC, Chien YH, Hu MH, Liu WS, Chen PW, Wang WH, Tzen KY, Byrne BJ, Hwu WL. Treatment of congenital neurotransmitter deficiencies by intracerebral ventricular injection of an adeno-associated virus serotype 9 vector. Hum Gene Ther. 2014 Mar;25(3):189-98. doi: 10.1089/hum.2013.170. Epub 2014 Jan 7.

53. Lin JC, Tarn WY, Hsieh WK. Emerging role for RNA binding motif protein 4 in the development of brown adipocytes. Biochim Biophys Acta. 2014 Apr;1843(4):769-79. doi: 10.1016/j.bbamcr.2013.12.018. Epub 2014 Jan 2.

54. Wang CH, Chen YF, Wu CY, Wu PC, Huang YL, Kao CH, Lin CH, Kao LS, Tsai TF, Wei YH. Cisd2 modulates the differentiation and functioning of adipocytes by regulating intracellular Ca2+ homeostasis. Hum Mol Genet. 2014 Sep 15;23(18):4770-85. doi: 10.1093/hmg/ddu193. Epub 2014 May 8.

55. Wu MY, Lin YC, Liao WJ, Tu CF, Chen MH, Roffler SR, Yang RB. Inhibition of the plasma SCUBE1, a novel platelet adhesive protein, protects mice against thrombosis. Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1390-8. doi: 10.1161/ATVBAHA.114.303779. Epub 2014 May 15.

56. Jiang-Xie LF, Liao HM, Chen CH, Chen YT, Ho SY, Lu DH, Lee LJ, Liou HH, Fu WM, Gau SS. Autism-associated gene Dlgap2 mutant mice demonstrate exacerbated aggressive behaviors and orbitofrontal cortex deficits. Mol Autism. 2014 May 1;5:32. doi: 10.1186/2040-2392-5-32. eCollection 2014.

57. Chen HR, Lin GT, Huang CK, Fann MJ. Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression. Exp Neurol. 2014 Nov;261:10-21. doi: 10.1016/j.expneurol.2014.06.024. Epub 2014 Jul 3.

58. Lo HC, Yang RB, Lee CH. Guanylyl cyclase-G modulates jejunal apoptosis and inflammation in mice with intestinal ischemia and reperfusion. PLoS One. 2014 Jul 3;9(7):e101314. doi: 10.1371/journal.pone.0101314. eCollection 2014.

59. Hung MH, Jian YR, Tsao CC, Lin SW, Chuang YH. Enhanced LPS-induced peritonitis in mice deficiency of cullin 4B in macrophages. Genes Immun. 2014 Sep;15(6):404-12. doi: 10.1038/gene.2014.32. Epub 2014 Jun 5.

60. Yu YR, You LR, Yan YT, Chen CM. Role of OVCA1/DPH1 in craniofacial abnormalities of Miller-Dieker syndrome. Hum Mol Genet. 2014 Nov 1;23(21):5579-96. doi: 10.1093/hmg/ddu273. Epub 2014 Jun 3.

61. Chao YC, Chen CC, Lin YC, Breer H, Fleischer J, Yang RB. Receptor guanylyl cyclase-G is a novel thermosensory protein activated by cool temperatures. EMBO J. 2015 Feb 3;34(3):294-306. doi: 10.15252/embj.201489652. Epub 2014 Dec 1.

62. Liao HJ, Chyuan IT, Wu CS, Lin SW, Chen KH, Tsai HF, Hsu PN. Increased neutrophil infiltration, IL-1 production and a SAPHO syndrome-like phenotype in PSTPIP2-deficient mice. Rheumatology (Oxford). 2015 Jul;54(7):1317-26. doi: 10.1093/rheumatology/keu481. Epub 2015 Jan 18.

63. Wu MJ, Wu WC, Chang HW, Lai YT, Lin CH, Yu WC, Chang VH. KLF10 affects pancreatic function via the SEI-1/p21Cip1 pathway. Int J Biochem Cell Biol. 2015 Mar;60:53-9. doi: 10.1016/j.biocel.2014.12.021. Epub 2015 Jan 9.

64. Hsu YJ, Yang SS, Cheng CJ, Liu ST, Huang SM, Chau T, Chu P, Salter DM, Lee HS, Lin SH. Thiazide‐Sensitive Naþ‐Cl Cotransporter (NCC) Gene Inactivation Results in Increased Duodenal Ca2þ Absorption, Enhanced Osteoblast Differentiation and Elevated Bone Mineral Density. J Bone Miner Res. 2015 Jan;30(1):116-27. doi: 10.1002/jbmr.2306.

65. Fang YW, Yang SS, Chau T, Nakamura M, Yamazaki O, Seki G, Yamada H, Hsu HM, Cheng CJ, Lin SH. Therapeutic effect of prenatal alkalization and PTC124 in Na(+)/HCO3(-) cotransporter 1 p.W516* knock-in mice. Gene Ther. 2015 May;22(5):374-81. doi: 10.1038/gt.2015.7. Epub 2015 Feb 26.

66. Lin YC, Roffler SR, Yan YT, Yang RB. Disruption of Scube2 Impairs Endochondral Bone Formation. J Bone Miner Res. 2015 Jul;30(7):1255-67. doi: 10.1002/jbmr.2451.

67. Tsai MS, Lee ML, Chang CY, Fan HH, Yu IS, Chen YT, You JY, Chen CY, Chang FC, Hsiao JH, Khorkova O, Liou HH, Yanagawa Y, Lee LJ, Lin SW. Functional and structural deficits of the dentate gyrus network coincide  
with emerging spontaneousseizures in an Scn1a mutant Dravet Syndrome model during development. Neurobiol Dis. 2015 May;77:35-48. doi: 10.1016/j.nbd.2015.02.010. Epub 2015 Feb 26.

68. Chang JY, Lee MH, Lin SR, Yang LY, Sun HS, Sze CI, Hong Q, Lin YS, Chou YT, Hsu LJ, Jan MS, Gong CX, Chang NS.Trafficking protein particle complex 6A delta (TRAPPC6AΔ) is an extracellular plaque-forming protein in the brain. Oncotarget. 2015 Feb 28;6(6):3578-89.

69. Yang SS, Huang CL, Chen HE, Tung CS, Shih HP, Liu YP. Effects of SPAK knockout on sensorimotor gating, 
novelty exploration, and brain area-dependentexpressions of NKCC1 and KCC2 in a mouse model of 
schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Aug 3;61:30-6. doi: 10.1016/j.pnpbp.2015.03.
007. Epub 2015 Mar 19.

70. Lin SH, Chien YC, Chiang WW, Liu YZ, Lien CC, Chen CC. Genetic mapping of ASIC4 and contrasting 
phenotype to ASIC1a in modulating innate fear and anxiety. Eur J Neurosci. 2015 Jun;41(12):1553-68. doi: 10.1111/ejn.12905. Epub 2015 May 4.

71. Lu LF, Gasteiger G, Yu IS, Chaudhry A, Hsin JP, Lu Y, Bos PD, Lin LL, Zawislak CL, Cho S, Sun JC, Leslie CS, Lin SW, Rudensky AY. A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-SpecificManner. Immunity. 2015 Jul 21;43(1):52-64. doi: 10.1016/j.immuni.2015.04.022. Epub 2015 Jul 7.

72. Lin HJ, Wu CP, Peng CK, Lin SH, Uchida S, Yang SS, Huang KL. With-No-Lysine Kinase 4 Mediates Alveolar Fluid Regulation in Hyperoxia-Induced Lung Injury. Crit Care Med. 2015 Oct;43(10):e412-9. doi: 10.1097/CCM.0000000000001144.

73. Lee NC, Muramatsu S, Chien YH, Liu WS, Wang WH, Cheng CH, Hu MK, Chen PW, Tzen KY, Byrne BJ, Hwu WL. Benefits of Neuronal Preferential Systemic Gene Therapy for Neurotransmitter Deficiency. Mol Ther. 2015 Oct;23(10):1572-81. doi: 10.1038/mt.2015.122. Epub 2015 Jul 3.

74. Wang KC, Li YH, Shi GY, Tsai HW, Luo CY, Cheng MH, Ma CY, Hsu YY, Cheng TL, Chang BI, Lai CH, Wu HL. Membrane-Bound Thrombomodulin Regulates Macrophage Inflammation in Abdominal Aortic Aneurysm. Arterioscler Thromb Vasc Biol. 2015 Nov;35(11):2412-22. doi: 10.1161/ATVBAHA.115.305529. Epub 2015 Sep 3.

75. Yung-Li Yang, Ching-Tzu Yen, Chen-Hsueh Pai, Hsuan-Yu Chen, Sung-Liang Yu,Chien-Yu Lin, Chung-Yi Hu, Shiann-Tarng Jou, Dong-Tsamn Lin, Shu-Rung Lin,Shu-Wha Lin. A Double Negative Loop Comprising ETV6/ RUNX1 and MIR181A1 Contributes to Differentiation Block in t(12;21)-Positive Acute Lymphoblastic Leukemia. PLoS One. 2015 Nov 18;10(11):e0142863. doi: 10.1371/journal.pone.0142863. eCollection 2015.

76. Chen HH, Chen WP, Yan WL, Huang YC, Chang SW, Fu WM, Su MJ, Yu IS, Tsai TC, Yan YT, Tsao YP, Chen SL. NRIP is newly identified as a Z-disc protein, activating calmodulin signaling for skeletal muscle contraction and regeneration. J Cell Sci. 2015 Nov 15;128(22):4196-209. doi: 10.1242/jcs.174441. Epub 2015 Oct 1.

77. Chien-Yu Lin, Chun-Yu Chen, Chih-Hsiang Yu, I-Shing Yu, Shu-Rung Lin, June- Tai Wu, Ying-Hung Lin, Pao-Lin, Kuo6, Jui-Ching Wu, Shu-Wha Lin. Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility. (Accepted) Sci Rep. 2016 Feb 2;6:20227. doi: 10.1038/srep20227.

78. Chang YT, Yang CC, Pan SY, Chou YH, Chang FC, Lai CF, Tsai MH, Hsu HL, Lin CH, Chiang WC, Wu MS, Chu TS, Chen YM, Lin SL. DNA methyltransferase inhibition restores erythropoietin production in fibrotic murine kidneys. J Clin Invest. 2016 Feb;126(2):721-31. doi: 10.1172/JCI82819. Epub 2016 Jan 5.

79. Fang YW, Yang SS, Cheng CJ, Tseng MH, Hsu HM, Lin SH. Chronic Metabolic Acidosis Activates Renal Tubular Sodium Chloride Cotransporter through Angiotension II-dependent WNK4-SPAK Phosphorylation Pathway. Sci Rep. 2016 Jan 5;6:18360. doi: 10.1038/srep18360.

80. Su TC, Lin SH, Lee PT, Yeh SH, Hsieh TH, Chou SY, Su TP, Hung JJ, Chang WC, Lee YC, Chuang JY. The sigma-1 receptor-zinc finger protein 179 pathway protects against hydrogen peroxide-induced cell injury. Neuropharmacology. 2016 Jun;105:1-9. doi: 10.1016/j.neuropharm.2016.01.015. Epub 2016 Jan 11.

81. Tsou JH, Yang YC, Pao PC, Lin HC, Huang NK, Lin ST, Hsu KS, Yeh CM, Lee KH, Kuo CJ, Yang DM, Lin JH, Chang WC, Lee YC. Important Roles of Ring Finger Protein 112 in Embryonic Vascular Development and Brain Functions. Mol Neurobiol. 2016 Mar 7. [Epub ahead of print]

82. Zhao H, Nepomuceno R, Gao X, Foley LM, Wang S, Begum G, Zhu W, Pigott VM, Falgoust LM, Kahle KT, Yang SS, Lin SH, Alper SL, Hitchens TK, Hu S, Zhang Z, Sun D. Deletion of the WNK3-SPAK kinase complex in mice improves radiographic and clinical outcomes in malignant cerebral edema after ischemic stroke. J Cereb Blood Flow Metab. 2017 Feb;37(2):550-563. doi: 10.1177/0271678X16631561. Epub 2016 Jul 20.

83. Tarn WY, Kuo HC, Yu HI, Liu SW, Tseng CT, Dhananjaya D, Hung KY, Tu CC, Chang SH, Huang GJ, Chiu IM. RBM4 promotes neuronal differentiation and neurite outgrowth by modulating Numb isoform expression. Mol Biol Cell. 2016 May 15;27(10):1676-83. doi: 10.1091/mbc.E15-11-0798. Epub 2016 Mar 23.

84. Chen CY, Chan CH, Chen CM, Tsai YS, Tsai TY, Wu Lee YH, You LR. Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis. Hum Mol Genet. 2016 Jul 15;25(14):2905-2922. Epub 2016 May 14.

85. Tsai LY, Chang YW, Lee MC, Chang YC, Hwang PI, Huang YS, Cheng CF. Biphasic and Stage-Associated Expression of CPEB4 in Hepatocellular Carcinoma. PLoS One. 2016 May 9;11(5):e0155025. doi: 10.1371/journal.pone.0155025. eCollection 2016.

86. Shyu YC, Lee TL, Lu MJ1, Chen JR, Chien RN, Chen HY, Lin JF8, Tsou AP, Chen YH, Hsieh CW, Huang TS. miR-122-mediated translational repression of PEG10 and its suppression in human hepatocellular carcinoma. J Transl Med. 2016 Jul 2;14(1):200. doi: 10.1186/s12967-016-0956-z.

87. Wang YT, Huang CC, Lin YS, Huang WF, Yang CY, Lee CC, Yeh CM, Hsu KS. Conditional deletion of Eps8 reduces hippocampal synaptic plasticity and impairs cognitive function. Neuropharmacology. 2017 Jan;112(Pt A):113-123. doi: 10.1016/j.neuropharm.2016.07.021. Epub 2016 Jul 20.

88. Lin TJ, Yang SS, Hua KF, Tsai YL, Lin SH, Ka SM. SPAK plays a pathogenic role in IgA nephropathy through the activation of NF-κB/MAPKs signaling pathway. Free Radic Biol Med. 2016 Oct;99:214-224. doi: 10.1016/j.freeradbiomed.2016.08.008. Epub 2016 Aug 9.

89. Huang YL, Chen ST, Liu RS, Chen YH6, Lin CY, Huang CH, Shu PY, Liao CL, Hsieh SL. CLEC5A is critical for dengue virus-induced osteoclast activation and bone homeostasis. J Mol Med (Berl). 2016 Sep;94(9):1025-37. doi: 10.1007/s00109-016-1409-0. Epub 2016 Mar 31.

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